Formulation Development and Optimization of Famotidine Mucoadhesive Tablets by Central Composite Design

Abstract: Objectives: The intention of present study is to formulate and optimize the famotidine mucoadhesive tablets y using Central Composite Design. Materials Methods: concentrations Cordia dichotoma fruit mucilage powder (X1) Polyvinyl pyrrolidone (X2) were demonstrated as independent variables. Whereas, dependent variables selected such an in vitro Mucoadhesion Time percentage Drug Release. model was considered be nonlinear curvature effect significant. Hence, reported By wet granulation method, prepared all formulated evaluated for its post compression parameters. Results: drug excipients had no interaction, according FT-IR DSC analyses. All formulations showed ranging from 5 hr 9 % Release range 96.4% 99.69%. association amongst variable judge by Contour plots. Conclusion: outcomes indicated efficacy proposed design Mucoadhesive development. Keywords: Optimization, Design, Release, Famotidine, Muco adhesive.